What to hang?

I've been thinking again about being in galleries, I had (or have) a chance to have a solo exhibit at Kirtland Community College, but I started wondering about what would go in it? Should I put a mash-up of artwork,have a theme or exhibit one of my series', such as Jack Nicholson or Popeye? Or both? I could go with a personal hero theme. If the opportunity arises, what do you think my exhibit should have?